Comorbidities and risk factors have been indicated to influence cancer care and outcome, with strong associations between the presence of comorbidities and patient survival. The objective of this study was to determine the pattern of comorbidities and risk factors among cancer patients. The study also intends to note any unrelated causes that people commonly associate with cancer that deviate their attention from true ones. Retrospective study design was used; data were collected from the patients who were diagnosed to have cancer and receiving chemotherapy in oncology ward. A total of 150 samples were selected for the study by convenient sampling technique. Among them, 88 patients were (58.7%) females and 62 (41.3%), males. Gastrointestinal tract cancer (19.3%), breast cancer (18.6%), and head and neck cancer (14.6%) are the cancers occurred most frequently. Comorbidities were present in all patients, with the most common being hypertension (37.3%), tuberculosis (22.6%), and diabetes mellitus (14.7%). Comorbidities occur significantly in cancer patients and influence the prognosis, treatment outcome, and survival rates of these patients. There is a need to routinely evaluate cancer patients for comorbidities and risk factors with the aim of instituting appropriate multidisciplinary management measures where necessary.