Chest drain tubes pose a patient for greater intensity of pain especially during its removal. It is important for the nurses to recognize the level of pain and treat it accordingly with non pharmacological treatments to prevent side effects and ease comfort. The study's objective is to evaluate the effectiveness of ice compress application by comparing the pre test and post test level of pain among the control and the experimental group of patients with chest drainage. The present study was conducted using experimental research design. A total of 60 patients with chest drainage were selected by systematic sampling method, among which 30 patients were assigned to control group and 30 patients to experimental group who satisfied the inclusion criteria. Data were collected using a demographic variable proforma, clinical variable proforma, numerical rating pain scale, and Mc Gill pain questionnaire. The results revealed that the scores between post test level of pain in the control group (Mean=7.06, SD=0.77) by Numerical rating scale, (M=2, SD=0.51) by Mc Gill pain questionnaire and experimental group (M=1.8, SD=1.11) by numerical rating scale, (M=0.1, SD=0) by Mc Gill pain questionnaire showed a statistically significant difference for ‘t’ value of 35.39 (NRS), 31.67 (Mc Gill Pain questionnaire )at p<0.001 which may be attributed to the ice compress application. The ice compress application has more significant effect upon the level of pain during chest drain removal.